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KMID : 0545119990090040525
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Journal of Microbiology and Biotechnology
1999 Volume.9 No. 4 p.525 ~ p.528
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Antimutagenic Potential of Phellinus igniarius
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Shon, Yun Hee
Lee, Jae Sung/Lee, Hang Woo/Nam, Kyung Soo
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Abstract
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Mutagenic activities of extracts from the filtrate of the cultured broth (PI-Ⅰ), mycelia (PI-Ⅱ), and the fruiting bodies (PI-Ⅲ) of Phellinus igniarius were examined by Ames/Salmonella tests. No mutagenic activity was found in Salmonella typhimurium strains TA98 and TA100, either with or without S9 activation. In contrast, PI-Ⅰ, PI-Ⅱ, and PI-Ⅲ showed inhibitory effects on the mutagenic activities by the directly-acting mutagens, 4-nitro-ο-phenylenediamine(NPD) and sodium azide (NaN_3), and also by the indirectly-acting mutagens, 2-aminofluorene (2-AF) and benzo[a]pyrene (B[a]P). These results suggest that P. igniarius possesses some antimutagenic activity and may contain some chemopreventive agents.
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